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IQ calmodulin-binding motif : ウィキペディア英語版 | IQ calmodulin-binding motif
The IQ calmodulin-binding motif is an amino acid sequence motif containing the following sequence: * ()Qxxx()Gxxx()xx() The term "IQ" refers to the first two amino acids of the motif: isoleucine (commonly) and glutamine (invariably). == Function ==
Calmodulin (CaM) is recognized as a major calcium (Ca2+) sensor and orchestrator of regulatory events through its interaction with a diverse group of cellular proteins. Three classes of recognition motifs exist for many of the known CaM binding proteins; the IQ motif as a consensus for Ca2+-independent binding and two related motifs for Ca2+-dependent binding, termed 1-14 and 1-5-10 based on the position of conserved hydrophobic residues.
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